Imaging in situ breast carcinoma (with or without an invasive component) with technetium-99m pentavalent dimercaptosuccinic acid and technetium-99m 2-methoxy isobutyl isonitrile scintimammography
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NUCLEAR PHARMACY Rapid Quality Control of Technetium-99m-2-Methoxy Isobutyl Isonitrile (Technetium-99m-Sestamibi)
Objective: Technetium-99m-sestamibi (-1"'Tc-MIBI) is a radiopharmaceutical imaging agent useful for assessing myocardial perfusion. We present a simple, rapid and accurate SepPak® method to confirm the radiochemical purity of "'Tc-MIBI. Methods: Technetium-99m-MIBI preparations of high (>95%), intermediate (83-90%) and low (25-43%) radiochemical purity were evaluated by the recommended thinlaye...
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Serial myocardial imaging with technetium-99m methoxyisobutyl isonitrile (9'Tc-MIBI) has been proposed for evaluating myocardial salvage after reperfusion. To define 'mTc-MIBI uptake before and after reperfusion, 17 open-chest dogs underwent 3 hours of left anterior descending artery occlusion and 3 hours of reperfusion. 9'Tc-MIBI was injected during occlusion (group 1) or after 90 minutes of r...
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To study the potential usefulness of technetium-99m hexakis-2-methoxy-2-methylpropyl-isonitrile (Tc-MIBI) as a cardiac perfusion imaging agent, the left circumflex coronary arteries of 12 dogs were partially occluded. Eight additional control dogs had no coronary artery stenosis. Myocardial Tc-MIBI activities in the left circumflex and left anterior descending zones were continuously monitored ...
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There are different scoring systems available for determining the grade of breast cancer malignancy. Breast cancer tumors have been described for grades 1-3 using the modified Nottingham-Bloom-Richardson grading system. Determining the grade is very important for the clinicians to choose the best treatment options. Technetium-99m methoxy isobutyl isonitrile ((99m)Tc-MIBI) and pentavalent (99m)T...
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ژورنال
عنوان ژورنال: Breast Cancer Research
سال: 2004
ISSN: 1465-542X
DOI: 10.1186/bcr948